Title : Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice.

Pub. Date : 2019 Sep 15

PMID : 31340160






1 Functional Relationships(s)
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1 In addition, 5 mg/kg andrographolide treatment also decreased the expression of pro-inflammatory mediators and cytokines (NO, COX-2, iNOS, IL-1beta, IL-6 and TNF-alpha), NF-kappaB signaling (p-p65, p-IkappaBalpha) and NLRP3 inflammasome assembly (NLRP3, ASC and caspase-1) in the prefrontal cortex. andrographolide caspase 1 Mus musculus