Pub. Date : 2019
PMID : 31339834
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5. | Steroids | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | PURPOSE: Hydroxylation activity at the 6beta-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (P450 or CYP) 3A4 and CYP3A5 and their molecular docking energy values were compared to understand the catalytic properties of the major forms of human CYP3A, namely, CYP3A4 and CYP3A5. | Steroids | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | PURPOSE: Hydroxylation activity at the 6beta-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (P450 or CYP) 3A4 and CYP3A5 and their molecular docking energy values were compared to understand the catalytic properties of the major forms of human CYP3A, namely, CYP3A4 and CYP3A5. | Steroids | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Maximal velocities (Vmax) of the three steroid hormones 6beta-hydroxylation catalyzed by CYP3A5 were 30%-63% of those by CYP3A4. | Steroids | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | The differences in the docking energies between CYP3A4 and CYP3A5 for steroid hormones were slightly correlated to the logarithm of CYP3A5/CYP3A4 ratios for Km values (substrate affinity). | Steroids | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | The differences in the docking energies between CYP3A4 and CYP3A5 for steroid hormones were slightly correlated to the logarithm of CYP3A5/CYP3A4 ratios for Km values (substrate affinity). | Steroids | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |