Title : Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV.

Pub. Date : 2019 Aug 29

PMID : 31339677






4 Functional Relationships(s)
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Compound Name
Protein Name
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1 BACKGROUND: Two drugs under consideration for inclusion in antiretroviral therapy (ART) regimens for human immunodeficiency virus (HIV) infection are dolutegravir (DTG) and tenofovir alafenamide fumarate (TAF). dolutegravir TATA-box binding protein associated factor 8 Homo sapiens
2 BACKGROUND: Two drugs under consideration for inclusion in antiretroviral therapy (ART) regimens for human immunodeficiency virus (HIV) infection are dolutegravir (DTG) and tenofovir alafenamide fumarate (TAF). dolutegravir TATA-box binding protein associated factor 8 Homo sapiens
3 CONCLUSIONS: Treatment with DTG combined with either of two tenofovir prodrugs (TAF and TDF) showed noninferior efficacy to treatment with the standard-care regimen. dolutegravir TATA-box binding protein associated factor 8 Homo sapiens
4 There was significantly more weight gain with the DTG-containing regimens, especially in combination with TAF, than with the standard-care regimen. dolutegravir TATA-box binding protein associated factor 8 Homo sapiens