Title : Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model.

Pub. Date : 2019

PMID : 31334116






3 Functional Relationships(s)
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1 In addition, co-treatment with a p53 inhibitor (cyclic pifithrin-alpha) and the ruthenium complexes significantly reduced the apoptosis rate in HCT116 cells, and increased phospho-p53 (S15) and phospho-histone H2AX (S139) expressions, indicating induction of DNA damage and p53-dependent apoptosis. pifithrin tumor protein p53 Homo sapiens
2 In addition, co-treatment with a p53 inhibitor (cyclic pifithrin-alpha) and the ruthenium complexes significantly reduced the apoptosis rate in HCT116 cells, and increased phospho-p53 (S15) and phospho-histone H2AX (S139) expressions, indicating induction of DNA damage and p53-dependent apoptosis. pifithrin tumor protein p53 Homo sapiens
3 In addition, co-treatment with a p53 inhibitor (cyclic pifithrin-alpha) and the ruthenium complexes significantly reduced the apoptosis rate in HCT116 cells, and increased phospho-p53 (S15) and phospho-histone H2AX (S139) expressions, indicating induction of DNA damage and p53-dependent apoptosis. pifithrin tumor protein p53 Homo sapiens