Pub. Date : 2019
PMID : 31333677
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes. | Tyrosine | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Tyrosine phosphorylation of the inflammasome sensors NLRP3, AIM2, NLRC4, and the adaptor protein, apoptosis-associated speck-like protein (ASC) has previously been demonstrated to be essential in the regulation of the inflammasome. | Tyrosine | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | By using the pharmacological protein tyrosine phosphatase (PTPase) inhibitor, phenylarsine oxide (PAO), we have demonstrated that tyrosine dephosphorylation is an essential step for the activation of the NLRP3 and AIM2 inflammasomes in human and murine macrophages. | Tyrosine | NLR family pyrin domain containing 3 | Homo sapiens |