Title : mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy.

Pub. Date : 2019 Jul 22

PMID : 31332166






1 Functional Relationships(s)
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1 First, strongly downregulated PARKIN and the mitophagic adaptor protein SQSTM1/p62 delays PINK1 activation to impair mitophagy induction after mitochondrial depolarization by CCCP or antimycin A plus oligomycin. Carbonyl Cyanide m-Chlorophenyl Hydrazone PTEN induced kinase 1 Homo sapiens