Pub. Date : 2019 Jul 22
PMID : 31332162
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes. | Palmitic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
2 | RNA sequencing revealed strong activation of the PI3K/Akt signaling pathway in T cells that were primed with PA. | Palmitic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
3 | Further mechanistic studies showed that inhibition of PI3K/Akt signaling, or its upstream mediator STAT5 can prevent PA-induced SLAMF3 upregulation on T cells. | Palmitic Acid | AKT serine/threonine kinase 1 | Homo sapiens |