Title : Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes.

Pub. Date : 2019 Jul 22

PMID : 31332162






3 Functional Relationships(s)
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1 Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes. Palmitic Acid AKT serine/threonine kinase 1 Homo sapiens
2 RNA sequencing revealed strong activation of the PI3K/Akt signaling pathway in T cells that were primed with PA. Palmitic Acid AKT serine/threonine kinase 1 Homo sapiens
3 Further mechanistic studies showed that inhibition of PI3K/Akt signaling, or its upstream mediator STAT5 can prevent PA-induced SLAMF3 upregulation on T cells. Palmitic Acid AKT serine/threonine kinase 1 Homo sapiens