Title : Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury.

Pub. Date : 2019 Sep 15

PMID : 31323261






2 Functional Relationships(s)
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1 Treatment with erastin upregulated Sesn2 mRNA levels and luciferase reporter gene activity, and erastin-mediated Sesn2 induction was transcriptionally regulated by NF-E2-related factor 2 (Nrf2). erastin nuclear factor, erythroid derived 2, like 2 Mus musculus
2 Furthermore, deletion of the antioxidant response element (ARE) in the Sesn2 promoter or Nrf2 knockout or knockdown abolished erastin-induced Sesn2 expression. erastin nuclear factor, erythroid derived 2, like 2 Mus musculus