Title : ERK-dependent proteasome degradation of Txnip regulates thioredoxin oxidoreductase activity.

Pub. Date : 2019 Sep 6

PMID : 31320475






1 Functional Relationships(s)
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1 We now show that tumor necrosis factor-alpha-induced Txnip degradation in A549 respiratory epithelial cells is regulated by the extracellular signal-regulated protein kinase (ERK) mitogen-activated protein kinase pathway and that ERK inhibition augments both intracellular reactive oxygen species and S-nitrosothiol. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens