Pub. Date : 2019 Sep 15
PMID : 31319070
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DOX markedly increased reactive oxygen species production, p53 expression, caspase-3 activity, cleaved caspase-3 levels, and TUNEL-positive cell numbers but reduced Bcl-2 expression and intracellular antioxidant enzyme levels; these effects were effectively antagonized through nicorandil (3 muM, 12 h) pretreatment, which resulted in HUVECs being protected from DOX-induced apoptosis. | Doxorubicin | tumor protein p53 | Homo sapiens |