Pub. Date : 2019 Oct
PMID : 31317427
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Spinocerebellar ataxia type 17 (SCA17) is caused by polyglutamine (polyQ) expansion in the TATA box-binding protein (TBP), which functions as a general transcription factor. | polyglutamine | ataxin 7 | Homo sapiens |
| 2 | Spinocerebellar ataxia type 17 (SCA17) is caused by polyglutamine (polyQ) expansion in the TATA box-binding protein (TBP), which functions as a general transcription factor. | polyglutamine | ataxin 7 | Homo sapiens |
| 3 | Spinocerebellar ataxia type 17 (SCA17) is caused by polyglutamine (polyQ) expansion in the TATA box-binding protein (TBP), which functions as a general transcription factor. | polyglutamine | ataxin 7 | Homo sapiens |
| 4 | Spinocerebellar ataxia type 17 (SCA17) is caused by polyglutamine (polyQ) expansion in the TATA box-binding protein (TBP), which functions as a general transcription factor. | polyglutamine | ataxin 7 | Homo sapiens |
| 5 | Like other polyQ expansion-mediated diseases, SCA17 is characterized by late-onset and selective neurodegeneration, despite the disease protein being ubiquitously expressed in the body. | polyglutamine | ataxin 7 | Homo sapiens |
| 6 | The well-characterized function of TBP and typical neurodegeneration in SCA17 give us opportunities to understand how polyQ expansion causes selective neurodegeneration and to develop effective therapeutics. | polyglutamine | ataxin 7 | Homo sapiens |