Title : Synergistic activation of thermogenic adipocytes by a combination of PPARĪ³ activation, SMAD3 inhibition and adrenergic receptor activation ameliorates metabolic abnormalities in rodents.

Pub. Date : 2019 Oct

PMID : 31317231






2 Functional Relationships(s)
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1 Moreover, the administration of rosiglitazone, SIS3 and the selective beta3 adrenergic receptor agonist CL316,243 to DIO mice reduced the amount of body-fat deposits (body weight from day 0 to 14, 12.3% reduction), concomitant with morphological changes in white adipose tissue, an increase in mitochondrial biosynthesis and a marked induction of uncoupling protein 1 (UCP1). Rosiglitazone uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
2 Moreover, the administration of rosiglitazone, SIS3 and the selective beta3 adrenergic receptor agonist CL316,243 to DIO mice reduced the amount of body-fat deposits (body weight from day 0 to 14, 12.3% reduction), concomitant with morphological changes in white adipose tissue, an increase in mitochondrial biosynthesis and a marked induction of uncoupling protein 1 (UCP1). Rosiglitazone uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus