Title : Synergistic activation of thermogenic adipocytes by a combination of PPARĪ³ activation, SMAD3 inhibition and adrenergic receptor activation ameliorates metabolic abnormalities in rodents.

Pub. Date : 2019 Oct

PMID : 31317231






1 Functional Relationships(s)
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1 RESULTS: Combined treatment with the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist rosiglitazone, the SMAD3 inhibitor SIS3 and the adrenergic receptor agonist noradrenaline (norepinephrine) synergistically induced Ucp1, Fgf21 and Cited1 expression, triggering brown adipogenesis. Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus