Title : Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation.

Pub. Date : 2019

PMID : 31316498






1 Functional Relationships(s)
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1 Importantly, pre-treatment of cells with the iron-chelating agent deferoxamine completely abolished the hemin-dependent translocation of 5-LOX to the nuclear fraction, and significantly reverted its effect on interleukin-6 overexpression. Deferoxamine arachidonate 5-lipoxygenase Homo sapiens