Title : Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication.

Pub. Date : 2019 Aug 30

PMID : 31315928






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 NS5A-D2 comprises a short structural motif (PW-turn) embedded in a proline-rich sequence, whose interaction with the human prolyl isomerase cyclophilin A (CypA) is essential for viral RNA replication. Proline peptidylprolyl isomerase A Homo sapiens
2 NS5A-D2 comprises a short structural motif (PW-turn) embedded in a proline-rich sequence, whose interaction with the human prolyl isomerase cyclophilin A (CypA) is essential for viral RNA replication. Proline peptidylprolyl isomerase A Homo sapiens