Pub. Date : 2019 Aug
PMID : 31306371
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, according to the hints provided by microarray-based transcriptional profiling, the results demonstrated that DHI treatment also promoted the activation of PI3K/AKT insulin signaling pathway induced by IRS-1 in aortas of HFD-induced atherosclerotic mice. | dehydrosoyasaponin I | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Furthermore, in an ox-LDL-induced macrophage model, the activation of PI3k/AKT signaling pathway also effectively functioned in the process of DHI inhibiting macrophage lipid accumulation. | dehydrosoyasaponin I | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | CONCLUSIONS: These results highlight that DHI treatment attenuates atherosclerosis and macrophage lipid accumulation by promoting the activation of PI3K/AKT insulin signaling pathway. | dehydrosoyasaponin I | thymoma viral proto-oncogene 1 | Mus musculus |