Pub. Date : 2020 Feb
PMID : 31301076
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin attenuates the paraquat-induced pulmonary fibrosis through activating Nrf2 pathway. | Paraquat | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | The nuclear factor E2-related factor 2 (Nrf2) plays an important regulatory role in the antioxidant therapy of PQ-induced pulmonary fibrosis. | Paraquat | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | The nuclear factor E2-related factor 2 (Nrf2) plays an important regulatory role in the antioxidant therapy of PQ-induced pulmonary fibrosis. | Paraquat | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | In this study, we tried to confirm that rapamycin attenuates PQ-induced pulmonary fibrosis by regulating Nrf2 pathway. | Paraquat | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | Furthermore, we also found that Nrf2 knockdown reduced the inhibitory effect of rapamycin on PQ-induced pulmonary fibrosis, as well as decreased Nrf2 transfer from the cytoplasm into the nucleus. | Paraquat | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 6 | Our findings demonstrated that the protective effect of rapamycin is associated with the activation of the Nrf2 pathway in pulmonary fibrosis induced by PQ poisoning. | Paraquat | NFE2 like bZIP transcription factor 2 | Homo sapiens |