Title : Solution NMR structure and ligand identification of human Gas7 SH3 domain reveal a typical SH3 fold but a non-canonical ligand-binding mode.

Pub. Date : 2019 Sep 3

PMID : 31296381






1 Functional Relationships(s)
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Protein Name
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1 Structural and sequence comparison showed that hGas7-SH3 shares high similarity with Abl SH3 domain, which binds to a high-affinity proline-rich peptide P41 in a canonical SH3-ligand binding mode through two hydrophobic pockets and a specificity site in the RT-loop. Proline mitogen-activated protein kinase 1 Homo sapiens