Pub. Date : 2019 Jul 1
PMID : 31288897
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 1,25(OH)2D3 inhibited LPS-stimulated phosphorylation of Akt at S473 and T308, IkappaBalpha phosphorylation, and nuclear accumulation of NF-kappaB. | Calcitriol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Blocking NF-kappaB signaling blunted the suppression effect of 1,25(OH)2D3 on IkappaBalpha phosphorylation, NF-kappaB accumulation in the nucleus and COX-2 expression. | Calcitriol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Blocking NF-kappaB signaling blunted the suppression effect of 1,25(OH)2D3 on IkappaBalpha phosphorylation, NF-kappaB accumulation in the nucleus and COX-2 expression. | Calcitriol | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | These results indicate that 1,25(OH)2D3 suppresses inflammatory response in LPS-induced HUVECs through PI3K/Akt/NF-kappaB signaling pathway. | Calcitriol | nuclear factor kappa B subunit 1 | Homo sapiens |