Title : Effect of polyamine depletion on c-myc expression in human colon carcinoma cells.

Pub. Date : 1988 Apr 25

PMID : 3128541






1 Functional Relationships(s)
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1 In the present study, we demonstrate that polyamine depletion induced by 2-difluoromethylornithine in COLO 320 human colon carcinoma cells results in a greater than 90% decrease in expression of a key gene in the maintenance of cell growth, the c-myc protooncogene. Eflornithine MYC proto-oncogene, bHLH transcription factor Homo sapiens