Pub. Date : 2019 Dec
PMID : 31279089
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulated thioredoxin and its reductase prevent H2O2-induced growth inhibition and death in human pulmonary artery smooth muscle cells. | Hydrogen Peroxide | thioredoxin | Homo sapiens |
| 2 | The present study investigated the roles of Trx1 and Trx reductase1 (TrxR1) proteins in regulation of cell growth, death, reactive oxygen species (ROS) and glutathione (GSH) levels in hydrogen peroxide (H2O2)-treated human pulmonary artery smooth muscle (HPASM) cells. | Hydrogen Peroxide | thioredoxin | Homo sapiens |
| 3 | The present study investigated the roles of Trx1 and Trx reductase1 (TrxR1) proteins in regulation of cell growth, death, reactive oxygen species (ROS) and glutathione (GSH) levels in hydrogen peroxide (H2O2)-treated human pulmonary artery smooth muscle (HPASM) cells. | Hydrogen Peroxide | thioredoxin | Homo sapiens |
| 4 | H2O2 induced growth inhibition and cell death in HPASM cells over 24 h. Overexpression of Trx1 and TrxR1 using adenoviruses significantly weakened cell growth inhibition and cell death caused by H2O2. | Hydrogen Peroxide | thioredoxin | Homo sapiens |
| 5 | H2O2 induced growth inhibition and cell death in HPASM cells over 24 h. Overexpression of Trx1 and TrxR1 using adenoviruses significantly weakened cell growth inhibition and cell death caused by H2O2. | Hydrogen Peroxide | thioredoxin | Homo sapiens |
| 6 | adTrx1 and adTrxR1 significantly reduced the increases in O2 - level in H2O2-treated HPASM cells at 24 h. Furthermore, HPASM cells transfected with Trx1 or TrxR1 siRNA showed increases in ROS levels with or without H2O2 at 5 min. | Hydrogen Peroxide | thioredoxin | Homo sapiens |
| 7 | In conclusion, upregulation of Trx1 and TrxR1 significantly attenuated cell growth inhibition and death in H2O2-treated HPASM cells. | Hydrogen Peroxide | thioredoxin | Homo sapiens |
| 8 | As a whole, Trx-related adenoviruses diminished H2O2-induced ROS level in HPASM cells whereas Trx-related siRNAs increased ROS levels and decreased GSH level in these cells. | Hydrogen Peroxide | thioredoxin | Homo sapiens |