Title : Potent and selective inhibition of human monoamine oxidase-B by 4-dimethylaminochalcone and selected chalcone derivatives.

Pub. Date : 2019 Sep 15

PMID : 31271801






1 Functional Relationships(s)
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1 Docking simulations showed binding affinities of compounds 1 to 5 for hMAO-B were higher than those for hMAO-A or AChE and suggested these five chalcones form hydrogen bonds with MAO-B at Cys172 but that they do not form hydrogen bonds with hMAO-A or AChE. Hydrogen acetylcholinesterase (Cartwright blood group) Homo sapiens