Title : Stereoselective Assembly of Multifunctional Spirocyclohexene Pyrazolones That Induce Autophagy-Dependent Apoptosis in Colorectal Cancer Cells.

Pub. Date : 2019 Jul 19

PMID : 31267754






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1 Enantio- and diastereoselective synthesis of multifunctional spiropyrazolone scaffolds has been achieved using secondary amine-catalyzed [4 + 2] annulations of alpha,beta,gamma,delta-unsaturated pyrazolones with aldehydes. Amines amyloid beta precursor protein Homo sapiens