Title : Histidine 64 is not required for high CO2 hydration activity of human carbonic anhydrase II.

Pub. Date : 1988 Mar 14

PMID : 3126084






1 Functional Relationships(s)
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1 To test the hypothesis that histidine 64 in carbonic anhydrase II has a crucial role as a "proton shuttle group" during catalysis of CO2-HCO3- interconversion, this residue was replaced by lysine, glutamine, glutamic acid and alanine by site-directed mutagenesis. Bicarbonates carbonic anhydrase 2 Homo sapiens