Title : Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis.

Pub. Date : 2019 Dec

PMID : 31257558






3 Functional Relationships(s)
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1 Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis. 14,15-epoxy-5,8,11-eicosatrienoic acid epoxide hydrolase 2 Rattus norvegicus
2 Inhibition of soluble epoxide hydrolase (sEHi) provides neuroprotection by blocking the degradation of 14,15-epoxyeicosatrienoic acid (14,15-EET), a lipid mediator whose synthesis can be activated downstream from group 1 metabotropic glutamate receptor (mGluR) signaling in astrocytes. 14,15-epoxy-5,8,11-eicosatrienoic acid epoxide hydrolase 2 Rattus norvegicus
3 Inhibition of soluble epoxide hydrolase (sEHi) provides neuroprotection by blocking the degradation of 14,15-epoxyeicosatrienoic acid (14,15-EET), a lipid mediator whose synthesis can be activated downstream from group 1 metabotropic glutamate receptor (mGluR) signaling in astrocytes. 14,15-epoxy-5,8,11-eicosatrienoic acid epoxide hydrolase 2 Rattus norvegicus