Title : The mitochondrial calcium uniporter contributes to morphine tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn.

Pub. Date : 2019 Aug

PMID : 31253357






2 Functional Relationships(s)
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1 RESULTS: Spinal morphine tolerance was associated with an increased expression of neuronal MCU, phospho-CREB (pCREB), and CPEB1 in the spinal cord dorsal horn. Morphine cAMP responsive element binding protein 1 Rattus norvegicus
2 Intrathecal antisense oligodeoxynucleotide against CREB or CPEB1 restored the anti-nociceptive effects of morphine compared with mismatch oligodeoxynucleotide in von Frey test and hotplate test. Morphine cAMP responsive element binding protein 1 Rattus norvegicus