Title : Unraveling Sugar Binding Modes to DC-SIGN by Employing Fluorinated Carbohydrates.

Pub. Date : 2019 Jun 25

PMID : 31242623






1 Functional Relationships(s)
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1 The combination of the 19F with standard proton saturation transfer difference (1H-STD-NMR) data, assisted by molecular dynamics (MD) simulations, permits us to successfully define this new binding epitope, where Man coordinates a Ca2+ ion of the lectin carbohydrate recognition domain (CRD) through the axial OH-2 and equatorial OH-3 groups, thus mimicking the Fuc/DC-SIGN binding architecture. Carbohydrates CD209 molecule Homo sapiens