Pub. Date : 2019 Dec
PMID : 31237151
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanistically, we show that TC-G 1008 mitigates IL-1beta-induced cell cycle arrest at G1 phase by suppressing the expression of p53, p21, PAI-1, and K382 acetylation of p53. | GPR39-C3 | tumor protein p53 | Homo sapiens |
| 2 | Mechanistically, we show that TC-G 1008 mitigates IL-1beta-induced cell cycle arrest at G1 phase by suppressing the expression of p53, p21, PAI-1, and K382 acetylation of p53. | GPR39-C3 | tumor protein p53 | Homo sapiens |
| 3 | Moreover, we show that TC-G 1008 treatment restores IL-1beta-induced inhibition of SIRT1 and the silencing of SIRT1 abolishes the function of TC-G 1008 on p53 acetylation and senescence, suggesting that the function of GPR39 signaling is mediated by SIRT1 in chondrocytes. | GPR39-C3 | tumor protein p53 | Homo sapiens |