Pub. Date : 2019 Dec
PMID : 31237151
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GPR39 agonist TC-G 1008 ameliorates IL-1beta-induced chondrocyte senescence. | GPR39-C3 | G protein-coupled receptor 39 | Homo sapiens |
| 2 | The GPR39 agonist TC-G 1008 mitigates IL-1beta-induced chondrocyte senescence. | GPR39-C3 | G protein-coupled receptor 39 | Homo sapiens |
| 3 | Moreover, we show that TC-G 1008 treatment restores IL-1beta-induced inhibition of SIRT1 and the silencing of SIRT1 abolishes the function of TC-G 1008 on p53 acetylation and senescence, suggesting that the function of GPR39 signaling is mediated by SIRT1 in chondrocytes. | GPR39-C3 | G protein-coupled receptor 39 | Homo sapiens |
| 4 | Altogether, our findings implicate that the activation of GPR39 signaling ameliorates IL-1beta-induced chondrocyte senescence and the GPR39 agonist TC-G 1008 could have the potential to modulate aging-associated OA. | GPR39-C3 | G protein-coupled receptor 39 | Homo sapiens |