Pub. Date : 2019 Jun 24
PMID : 31235707
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At sub-MIC concentrations, fluconazole and miconazole stimulate catalase activity 2-3-fold but, unexpectedly, deletion of cytosolic catalase (ctt1) makes cells more resistant to these azoles and to clotrimazole, itraconazole and posaconazole. | Azoles | catalase T | Saccharomyces cerevisiae S288C |
| 2 | Since H2O2 preconditioning does not alter the resistance of ctt1Delta cells, which possess negligible catalase activity, we link azole potentiation with Ctt1 upregulation. | Azoles | catalase T | Saccharomyces cerevisiae S288C |
| 3 | In fact, the ctt1Delta mutant has double the Sod2 activity of wild-type cells so ctt1 deletion increases azole resistance in part by Sod2 upregulation. | Azoles | catalase T | Saccharomyces cerevisiae S288C |