Title : Rosiglitazone increases expression of steroidogenic acute regulatory protein and progesterone production through PPARĪ³-EGFR-ERK1/2 in human cumulus granulosa cells.

Pub. Date : 2019 Oct

PMID : 31233701






2 Functional Relationships(s)
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1 Addition of ERK1/2 (U0126), EGFR (AG1478) and PPARgamma (GW9662) inhibitors prevented the ROSI-induced STAR mRNA expression and progesterone production after 48h. Progesterone mitogen-activated protein kinase 3 Homo sapiens
2 Overall, these data suggested that PPARgamma, EGFR and ERK1/2 were involved in the stimulatory effect of ROSI on STAR expression and progesterone production in undifferentiated human cumulus granulosa cells. Progesterone mitogen-activated protein kinase 3 Homo sapiens