Title : Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals.

Pub. Date : 2019 Jun 21

PMID : 31232697






1 Functional Relationships(s)
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1 Taken together, our results revealed that pyrimidine intermediates increased lifespan by inhibiting reproductive signals and subsequently inducing the function of DAF-12, NHR-49 and DAF-16 in C. elegans. pyrimidine Nuclear hormone receptor family member daf-12 Caenorhabditis elegans