Title : Propranolol inhibits neonatal Nav1.5 activity and invasiveness of MDA-MB-231 breast cancer cells: Effects of combination with ranolazine.

Pub. Date : 2019 Dec

PMID : 31222761






4 Functional Relationships(s)
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1 Short-term (acute) application of the beta-AR antagonist propranolol (25 muM) led to reduction of peak current and quickening of current inactivation (the latter occurred only in 5% fetal bovine serum). Propranolol latexin Homo sapiens
2 Long-term (48 hr) incubation with propranolol (25 muM) resulted in several changes in VGSC characteristics: shifts in (a) current-voltage relationship and (b) steady-state inactivation, both to more negative potentials and (c) the slowing of recovery from inactivation. Propranolol latexin Homo sapiens
3 Propranolol (2.5 and 25 muM) and ranolazine (5 muM), and their combination inhibited lateral motility. Propranolol latexin Homo sapiens
4 Also, propranolol (25 muM) and ranolazine (5 muM), and their combination inhibited invasion. Propranolol latexin Homo sapiens