Pub. Date : 2019
PMID : 31218953
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The combination of As2O3 with resveratrol, on the one hand reduced the expression of hERG channels on the membrane, and on the other hand weaken the binding between hERG and integrin beta 1, which may be the main cause of downstream signaling pathways alterations, including the activation of the apoptotic pathway. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 2 | The combination of As2O3 with resveratrol, on the one hand reduced the expression of hERG channels on the membrane, and on the other hand weaken the binding between hERG and integrin beta 1, which may be the main cause of downstream signaling pathways alterations, including the activation of the apoptotic pathway. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 3 | CONCLUSION: Taken together, hERG, as a subunit of potassium ion channel on the cell membrane, is highly likely to be involved in the As2O3 and resveratrol induced intracellular signaling cascade disorder, and this novel signaling pathway that sustains the progression of colon cancer may be a promising therapeutic target for human colon cancer treatment in the future. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |