Title : The contribution of S100B to the glioprotective effects of valproic and arundic acids.

Pub. Date : 2019 May

PMID : 31217937






3 Functional Relationships(s)
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1 In this study, we aimed to assess the glioprotective effects of valproic and arundic acids against amyloid-beta-peptide (Abeta)-induced glial death and contribution of S100B to the glioprotective effects of these agents in an astrocytic culture. Valproic Acid amyloid beta precursor protein Homo sapiens
2 Valproic acid (0.5 and 1 mM) and arundic acid (50 microM) ameliorated the gliotoxic effects of Abeta (P<0.05). Valproic Acid amyloid beta precursor protein Homo sapiens
3 Arundic and valproic acids (0.5 and 1 mM) decreased both the intracellular and extracellular S100B levels compared to the Abeta-treated group (P<0.001). Valproic Acid amyloid beta precursor protein Homo sapiens