Pub. Date : 2019 Oct
PMID : 31202736
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we showed that treatment with the indirect CAR activator phenobarbital activated transcription of the CYP3A4 gene in three-dimensionally (3D)-cultured HepG2 cells. | Phenobarbital | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Moreover, okadaic acid and epidermal growth factor, were found to repress phenobarbital-induced CAR nuclear translocation and subsequent activation of the CYP3A4 gene promoter. | Phenobarbital | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |