Title : 1α,25-dihydroxyvitamin D3 attenuates oxidative stress-induced damage in human trabecular meshwork cells by inhibiting TGFβ-SMAD3-VDR pathway.

Pub. Date : 2019 Aug 13

PMID : 31196627






2 Functional Relationships(s)
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1 Mechanistically, our findings revealed that H2O2-induced damage was mediated by the transforming growth factor-beta (TGF-beta)-SMAD3 pathway in HTMCs, and 1, 25-(OH)2D3 could protect HTMCs against oxidative stress through vitamin D receptor (VDR), which antagonises the effects of SMAD3. Hydrogen Peroxide transforming growth factor beta 1 Homo sapiens
2 Mechanistically, our findings revealed that H2O2-induced damage was mediated by the transforming growth factor-beta (TGF-beta)-SMAD3 pathway in HTMCs, and 1, 25-(OH)2D3 could protect HTMCs against oxidative stress through vitamin D receptor (VDR), which antagonises the effects of SMAD3. Hydrogen Peroxide transforming growth factor beta 1 Homo sapiens