Pub. Date : 2020 Feb 15
PMID : 31187490
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression. | Tretinoin | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 2 | Notably, CSC marker aldehyde dehydrogenase 1A1 (ALDH1A1), a critical enzyme that synthesizes retinoic acid (RA), was abundantly expressed in PDCs. | Tretinoin | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 3 | Notably, CSC marker aldehyde dehydrogenase 1A1 (ALDH1A1), a critical enzyme that synthesizes retinoic acid (RA), was abundantly expressed in PDCs. | Tretinoin | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 4 | Notably, CSC marker aldehyde dehydrogenase 1A1 (ALDH1A1), a critical enzyme that synthesizes retinoic acid (RA), was abundantly expressed in PDCs. | Tretinoin | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 5 | Notably, CSC marker aldehyde dehydrogenase 1A1 (ALDH1A1), a critical enzyme that synthesizes retinoic acid (RA), was abundantly expressed in PDCs. | Tretinoin | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 6 | ALDH1A1 inhibitors and shRNAs repressed both PDC proliferation and spheroid formation, whereas all-trans RA could rescue ALDH1A1 shRNA-suppressed spheroid formation. | Tretinoin | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |