Title : Metformin induces TPC-1 cell apoptosis through endoplasmic reticulum stress-associated pathways in vitro and in vivo.

Pub. Date : 2019 Jul

PMID : 31180536






2 Functional Relationships(s)
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1 In addition, treatment with metformin increased the expression of Bip, CHOP and caspase-12 in vitro, activating endoplasmic reticulum (ER) stress. Metformin DNA damage inducible transcript 3 Homo sapiens
2 Finally, treatment with metformin inhibited thyroid cancer growth and increased the expression of Bip and CHOP in a TPC-1 cell xenograft model. Metformin DNA damage inducible transcript 3 Homo sapiens