Pub. Date : 2019 Sep
PMID : 31176046
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The neuroprotection of progesterone against Abeta-induced NLRP3-Caspase-1 inflammasome activation via enhancing autophagy in astrocytes. | Progesterone | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | However, the exact role of PG in regulating NLRP3-Caspase-1 inflammasome remains to be elucidated. | Progesterone | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Remarkably, PG significantly inhibited Abeta-induced NLRP3-Caspase-1 inflammasome activation. | Progesterone | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Autophagy inhibitor 3-MA blocked the protective effects of PG in mediating NLRP3 inflammasome and IL-1beta processing. | Progesterone | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Taken together, our observations suggest that autophagy-lysosome pathway is one specific molecular mechanism in regulating Abeta-induced NLRP3-Caspase-1 inflammasome activation in astrocytes, particularly uncover the potential neuroprotection of PG in regulating upstream signaling leading to the sequence events of neuroinflammation. | Progesterone | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | That neuroprotective mechanism of PG in regulating NLRP3-Caspase-1 inflammasome can be a potential therapeutic target for ameliorating the pathological procession of AD. | Progesterone | NLR family pyrin domain containing 3 | Homo sapiens |