Title : Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment.

Pub. Date : 2019 Sep

PMID : 31175983






3 Functional Relationships(s)
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1 Surprisingly, our results show that in PD substantia nigra, the hMPO gene is expressed in neurons containing aggregates of nitrated alphaSyn as well as MPO-generated HOCl-modified epitopes. Hypochlorous Acid myeloperoxidase Homo sapiens
2 Surprisingly, our results show that in PD substantia nigra, the hMPO gene is expressed in neurons containing aggregates of nitrated alphaSyn as well as MPO-generated HOCl-modified epitopes. Hypochlorous Acid myeloperoxidase Homo sapiens
3 In the mouse model, hMPO was expressed in neurons colocalizing with nitrated alphaSyn, carbamylated lysine, nitrotyrosine, as well as HOCl-modified epitopes/proteins. Hypochlorous Acid myeloperoxidase Homo sapiens