Pub. Date : 2019 Jun 7
PMID : 31174572
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calycosin suppresses TGF-beta-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 2 | RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 3 | RESULTS: Calycosin up-regulated the expression of BATF2 via the signal transducer and activator of transcription 3 (STAT3) pathway, which was antagonized by transforming growth factor beta (TGF-beta), calycosin promoted the cell apoptosis and growth inhibition via phosphoinositide 3-kinase (PI3K)/Akt pathway. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 4 | TGF-beta promoted cell growth, which was inhibited by calycosin regulating the expression of proliferating cell nuclear antigen (PCNA) via the phosphoinositide 3-kinase pathway. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 5 | TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 6 | TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 7 | TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 8 | TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 9 | TGF-beta suppressed expression of BAX via the phosphoinositide 3-kinase pathway but induced cell apoptosis .calycosin enhanced the effect of TGF-beta on cell apoptosis,In addition, calycosin suppressed TGF-beta-induced cell migration by increasing BATF2 to target PAI-1. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |
| 10 | TGF-beta-induced EMT was inhibited by calycosin in human CRC LoVo and HCT116 cell lines via the Wnt signaling pathway. | 7,3'-dihydroxy-4'-methoxyisoflavone | transforming growth factor beta 1 | Homo sapiens |