Title : Drug-Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC-122) in Healthy Adult Subjects.

Pub. Date : 2019 Dec

PMID : 31172535






1 Functional Relationships(s)
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1 Avadomide exposures, when coadministered with the CYP3A inhibitor itraconazole, were 100.0% and 93.64% of that when administered alone, for AUC0-inf and Cmax , respectively. Itraconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens