Title : The combination therapy of HIF1α inhibitor LW6 and cisplatin plays an effective role on anti-tumor function in A549 cells.

Pub. Date : 2019 Sep

PMID : 31169018






2 Functional Relationships(s)
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1 LW6-treated A549 cells showed an increase in ROS level that blocked the hypoxia induced resistance to cisplatin and in addition, decreased expression of MDR1 and MRP1 in cisplatin-treated cells. Cisplatin ATP binding cassette subfamily B member 1 Homo sapiens
2 This study revealed that hypoxia-improved cisplatin chemoresistance of NSCLC cells by regulated MDR1 and MRP1 expression via HIF1alpha/ROS pathway is reversed by LW6, suggesting that LW6 may act as effective sensitizer in chemotherapy for NSCLC. Cisplatin ATP binding cassette subfamily B member 1 Homo sapiens