Title : Capsaicin enhances erlotinib-induced cytotoxicity via AKT inactivation and excision repair cross-complementary 1 (ERCC1) down-regulation in human lung cancer cells.

Pub. Date : 2019 May 1

PMID : 31160978






5 Functional Relationships(s)
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1 Capsaicin enhances erlotinib-induced cytotoxicity via AKT inactivation and excision repair cross-complementary 1 (ERCC1) down-regulation in human lung cancer cells. Capsaicin AKT serine/threonine kinase 1 Homo sapiens
2 In this study, capsaicin decreased the ERCC1 expression in an AKT inactivation dependent manner in two human lung adenocarcinoma cells, namely, A549 and H1975. Capsaicin AKT serine/threonine kinase 1 Homo sapiens
3 Enhancement of AKT activity by transfection with constitutive active AKT vectors increased the ERCC1 protein level as well as the cell survival by capsaicin. Capsaicin AKT serine/threonine kinase 1 Homo sapiens
4 Enhancement of AKT activity by transfection with constitutive active AKT vectors increased the ERCC1 protein level as well as the cell survival by capsaicin. Capsaicin AKT serine/threonine kinase 1 Homo sapiens
5 Moreover, capsaicin synergistically enhanced the cytotoxicity and cell growth inhibition of erlotinib in NSCLC cells, which were associated with the down-regulation of ERCC1 expression and inactivation of AKT in A549 and H1975 cells. Capsaicin AKT serine/threonine kinase 1 Homo sapiens