Title : Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction.

Pub. Date : 2019 Aug 9

PMID : 31160323






1 Functional Relationships(s)
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1 Here we present the crystal structures of hAPRT complexed to three cellular nucleotide analogs (hypoxanthine, IMP, and GMP) that we compare with the phosphate-bound enzyme. Inosine Monophosphate adenine phosphoribosyltransferase Homo sapiens