Title : Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives.

Pub. Date : 2019 Aug

PMID : 31158577






1 Functional Relationships(s)
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1 Amongst them, 7k, 7m and 7p, all with a 6 carbon linker between tacrine and isatin Schiff base exhibited the strongest inhibitory activity against AChE with IC50 values of 0.42 nM, 0.62 nM and 0.95 nM, respectively. Carbon acetylcholinesterase (Cartwright blood group) Homo sapiens