Title : Structure-based design and synthesis of new 4-methylcoumarin-based lignans as pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) inhibitors.

Pub. Date : 2019 Aug

PMID : 31153100






1 Functional Relationships(s)
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1 Suppression of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) along with nitric oxide reduction in RAW 264.7 cells by 7,8-dihydroxy-4-methylcoumarin, ethyl p-coumarate, ethyl caffeate and ethyl ferulate drove us to search structural-analogues of the aforementioned compounds through structure-based drug design. 7,8-dihydroxy-4-methylcoumarin interleukin 6 Mus musculus