Pub. Date : 2019 Aug 25
PMID : 31152735
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of astrocyte conditioned medium on neuronal AChE expression upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. | Polychlorinated Dibenzodioxins | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Emerging evidence has shown that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a typical persistent organic pollutant, suppressed neuronal AChE activity via dysregulation of different biosynthesis processes in human and rat neuronal cells. | Polychlorinated Dibenzodioxins | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | Emerging evidence has shown that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a typical persistent organic pollutant, suppressed neuronal AChE activity via dysregulation of different biosynthesis processes in human and rat neuronal cells. | Polychlorinated Dibenzodioxins | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | As a known target cell of TCDD, the astrocyte might be involved in TCDD effects on neuronal AChE. | Polychlorinated Dibenzodioxins | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | As a known target cell of TCDD, the astrocyte might be involved in TCDD effects on neuronal AChE. | Polychlorinated Dibenzodioxins | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | The enzymatic activity of AChE was generally decreased in cultured cortical neurons upon direct treatment with TCDD (0.003-0.01 nM). | Polychlorinated Dibenzodioxins | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 7 | Compared with effects of treatment with ACM plus TCDD (ACMT), a significant differential effect on AChE activity was found in the TACM group in response to TCDD treatment specifically in immature neurons, suggesting the presence of a TCDD-specific active component derived from the astrocyte. | Polychlorinated Dibenzodioxins | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 8 | These data indicate that the astrocyte might play a protective role in TCDD-induced alterations of neuronal AChE in certain stages of differentiation. | Polychlorinated Dibenzodioxins | acetylcholinesterase (Cartwright blood group) | Homo sapiens |