Title : Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the α7 Nicotinic Acetylcholine Receptor.

Pub. Date : 2019 Jul 15

PMID : 31152077






4 Functional Relationships(s)
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1 In addition, nicotine significantly enhanced PI3K/Akt and inhibited NF-kappaB translocation from the cytosol to the nucleus in an alpha7-nAChR-dependent manner, suggesting that nicotine acts on alpha7-nAChRs to inhibit MMP-9 production by macrophages through modulation of the PI3K/Akt-NF-kappaB pathway. Nicotine thymoma viral proto-oncogene 1 Mus musculus
2 In addition, nicotine significantly enhanced PI3K/Akt and inhibited NF-kappaB translocation from the cytosol to the nucleus in an alpha7-nAChR-dependent manner, suggesting that nicotine acts on alpha7-nAChRs to inhibit MMP-9 production by macrophages through modulation of the PI3K/Akt-NF-kappaB pathway. Nicotine thymoma viral proto-oncogene 1 Mus musculus
3 In addition, nicotine significantly enhanced PI3K/Akt and inhibited NF-kappaB translocation from the cytosol to the nucleus in an alpha7-nAChR-dependent manner, suggesting that nicotine acts on alpha7-nAChRs to inhibit MMP-9 production by macrophages through modulation of the PI3K/Akt-NF-kappaB pathway. Nicotine thymoma viral proto-oncogene 1 Mus musculus
4 In addition, nicotine significantly enhanced PI3K/Akt and inhibited NF-kappaB translocation from the cytosol to the nucleus in an alpha7-nAChR-dependent manner, suggesting that nicotine acts on alpha7-nAChRs to inhibit MMP-9 production by macrophages through modulation of the PI3K/Akt-NF-kappaB pathway. Nicotine thymoma viral proto-oncogene 1 Mus musculus